Epigenetic clock
Changes in DNA methylation occurring with aging, can accurately predict life expectancy. Higher mortality rates have been observed among individuals with DNA methylation age exceeding their chronological age. We will use a mouse liver transplantation assay and implant old hepatocytes in young animals and vice versa. Using this approach, we will examine whether the DNA methylation clock can be reversed in fully differentiated cells. This will deepen our understanding of the mechanisms governing the DNA methylation clock rate and its impact on aging.
